Postprandial metabolism in adults with prader-willi syndrome

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Erratum: Postprandial metabolism in adults with prader-willi syndrome.

OBJECTIVE Individuals with Prader-Willi syndrome (PWS) are commonly restricted to 60-75% of height-appropriate calorie intake because they rapidly become obese on a normal diet. This study measured changes in energy expenditure, glucose and lipid homeostasis, and metabolic flexibility in response to a meal in PWS adults. METHODS 11 adults with PWS were compared with 12 adiposity-matched and 1...

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Lack of Postprandial Peak in Brain-Derived Neurotrophic Factor in Adults with Prader-Willi Syndrome

CONTEXT Prader-Willi syndrome (PWS) is characterized by severe hyperphagia. Brain-derived neurotrophic factor (BDNF) and leptin are reciprocally involved in energy homeostasis. OBJECTIVES To analyze the role of BDNF and leptin in satiety in genetic subtypes of PWS. DESIGN Experimental study. SETTING University hospital. SUBJECTS 90 adults: 30 PWS patients; 30 age-sex-BMI-matched obese c...

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Growth Hormone Therapy in Adults with Prader-Willi Syndrome

Prader-Willi syndrome (PWS) is characterized by hyperphagia, obesity if food intake is not strictly controlled, abnormal body composition with decreased lean body mass and increased fat mass, decreased basal metabolic rate, short stature, low muscle tone, cognitive disability, and hypogonadism. In addition to improvements in linear growth, the benefits of growth hormone therapy on body composit...

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Dental Management of Patients with Prader Willi Syndrome

Prader–Willi syndrome (PWS) is a genetic disorder which occurs with a frequency of about one in 10,000–30,000 live newborns. Both males and females, and all races are equally affected. PWS is a complex disorder with multiple disabilities, and the main defect is found in the hypothalamus. Child with PWS at the age between 2 and 3 years becomes constantly hungry and if the diet is not controlled,...

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Underwater Weighing Familiarization Program for Adults with Prader-Willi Syndrome.

The purpose of the project was to evaluate an underwater weighing (UWW) and residual lung volume (RV) familiarization program developed for adults with Prader-Willi syndrome (PWS). UWW was conducted on 15 adults (10 men, 5 women) with PWS following a UWW familiarization program. Repeated measures ANOVA revealed no difference in percent body fat derived from UWW over the four sessions, F(3, 27) ...

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ژورنال

عنوان ژورنال: Obesity

سال: 2015

ISSN: 1930-7381

DOI: 10.1002/oby.21041